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A situation report by Videtic and Venkatesan [44] famous the helpful effects of HBOT on sacral plexopathy causing severe pelvic pain within a 55-yr-old female. While the HBOT sign was for sacral osteoradionecrosis as a result of radiotherapy for bladder leiomyosarcoma, intense pain was a major symptom. Her pain wasn't responding to opioid analgesic